We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Insulin Sensitivity and the Risk of Incident Hypertension.
- Authors
Goff Jr., David C.; Zaccaro, Daniel J.; Haffner, Steven M.; Saad, Mohammed F.
- Abstract
OBJECTIVE -- The insulin resistance syndrome has been described as including hypertension. Previous studies have documented cross-sectional associations between insulin sensitivity (S[subI]) and blood pressure or prevalent hypertension. Prospective data have been sparse. RESEARCH DESIGN AND METHODS -- The Insulin Resistance Atherosclerosis Study (IRAS) is a prospective study of the associations of S[subI] with atherosclerosis and other risk factors for cardiovascular disease. We examined the association between S[subI], measured using the frequently sampled intravenous glucose tolerance test with minimal model analysis, and incident hypertension (defined as per the Joint National Committee), at the 5-year examination in 840 IRAS participants who were free of hypertension at the baseline examination. RESULTS -- Adjusted for age, sex, ethnicity, and smoking status, for each unit greater S[subI], the risk of hypertension was 10% lower (95% CI 2-19, P < 0.05). CONCLUSIONS -- These findings, from a prospective study, support the presence of a modest protective association between greater S[subI] and lower risk of hypertension. These findings support the contention that interventions that improve S[subI] may be beneficial with respect to the development of hypertension and cardiovascular disease. This contention should be tested in randomized clinical trials.
- Subjects
INSULIN resistance; HYPERTENSION; DIABETES
- Publication
Diabetes Care, 2003, Vol 26, Issue 3, p805
- ISSN
0149-5992
- Publication type
Article
- DOI
10.2337/diacare.26.3.805