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- Title
Coupling between cerebrovascular oscillations and CSF flow fluctuations during wakefulness: An fMRI study.
- Authors
Yang, Ho-Ching; Inglis, Ben; Talavage, Thomas M; Nair, Vidhya Vijayakrishnan; Yao, Jinxia; Fitzgerald, Bradley; Schwichtenberg, Amy J; Tong, Yunjie
- Abstract
It is commonly believed that cerebrospinal fluid (CSF) movement is facilitated by blood vessel wall movements (i.e., hemodynamic oscillations) in the brain. A coherent pattern of low frequency hemodynamic oscillations and CSF movement was recently found during non-rapid eye movement (NREM) sleep via functional MRI. This finding raises other fundamental questions: 1) the explanation of coupling between hemodynamic oscillations and CSF movement from fMRI signals; 2) the existence of the coupling during wakefulness; 3) the direction of CSF movement. In this resting state fMRI study, we proposed a mechanical model to explain the coupling between hemodynamics and CSF movement through the lens of fMRI. Time delays between CSF movement and global hemodynamics were calculated. The observed delays between hemodynamics and CSF movement match those predicted by the model. Moreover, by conducting separate fMRI scans of the brain and neck, we confirmed the low frequency CSF movement at the fourth ventricle is bidirectional. Our finding also demonstrates that CSF movement is facilitated by changes in cerebral blood volume mainly in the low frequency range, even when the individual is awake.
- Publication
Journal of Cerebral Blood Flow & Metabolism, 2022, Vol 42, Issue 6, p1091
- ISSN
0271-678X
- Publication type
Article
- DOI
10.1177/0271678X221074639