We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Genetic variability of Leishmania (Leishmania) infantum causing human visceral leishmaniasis in the Southeastern Brazil.
- Authors
Alves Lima, Vinicius; Costa Silva, Renata Elen; Moraes Caetano Camargo, Luiz Henrique; Mitsuyoshi Hiramoto, Roberto; de Souza Leal, Elcio; Almeida Braz, Lucia Maria; Lauletta Lindoso, José Angelo
- Abstract
Leishmania infantum is a protozoan that causes visceral leishmaniasis (VL) in the Americas and some regions of Europe. The disease is mainly characterized by hepatosplenomegaly and fever, and can be fatal. Factors related to the host and parasite can contribute to the transmission of Leishmania and the clinical outcome. The intraspecific genetic variability of L. infantum strains may be one of these factors. In this study, we evaluated the genetic variability of L. infantum obtained from bone marrow smear slides from patients in the Sao Paulo State, Brazil. For this, the minicircle of the kDNA hypervariable region was used as target by Sanger sequencing. By analyzing the similarity of the nucleotides and the maximum likelihood tree (Fasttree), we observed a high similarity (98%) among samples. Moreover, we identified four different profiles of L. infantum. In conclusion, L. infantum strains from Sao Paulo State, Brazil, showed low diversity measured by minicircle of the kDNA hypervariable region.
- Subjects
SAO Paulo (Brazil : State); BRAZIL; VISCERAL leishmaniasis; GENETIC variation; LEISHMANIA; TREATMENT effectiveness; LEISHMANIA infantum; HYPERVARIABLE regions
- Publication
Revista do Instituto de Medicina Tropical de São Paulo, 2023, Vol 65, p1
- ISSN
0036-4665
- Publication type
Article
- DOI
10.1590/S1678-9946202365055