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- Title
WASP: allele-specific software for robust molecular quantitative trait locus discovery.
- Authors
van de Geijn, Bryce; McVicker, Graham; Gilad, Yoav; Pritchard, Jonathan K
- Abstract
Allele-specific sequencing reads provide a powerful signal for identifying molecular quantitative trait loci (QTLs), but they are challenging to analyze and are prone to technical artifacts. Here we describe WASP, a suite of tools for unbiased allele-specific read mapping and discovery of molecular QTLs. Using simulated reads, RNA-seq reads and chromatin immunoprecipitation sequencing (ChIP-seq) reads, we demonstrate that WASP has a low error rate and is far more powerful than existing QTL-mapping approaches.
- Subjects
ALLELES; SIMULATION methods &; models; IMMUNOPRECIPITATION; CHROMATIN; ERROR rates
- Publication
Nature Methods, 2015, Vol 12, Issue 11, p1061
- ISSN
1548-7091
- Publication type
Article
- DOI
10.1038/nmeth.3582