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- Title
Stability Testing of Beclomethasone Dipropionate Nanoemulsion.
- Authors
Alam, Mohammad Sarfaraz; Ali, Mohammad Sajid; Alam, Mohammad Intakhab; Anwer, Tarique; Safhi, Mohammed Mohsen A.
- Abstract
Purpose: To perform stability studies on a nanoemulsion formulation containing beclomethasone dipropionate (BD) and prepared by spontaneous emulsification method. Method: A nanoemulsion (o/w) containing BD was prepared using eucalyptus oil, Tween-40, ethanol and distilled water. The nanoemulsions were characterized by droplet size, pH, viscosity, conductivity and refractive index. Stability studies were performed according to International Council on Harmonization (ICH) guidelines over a period of 3 months. Droplet size, pH, viscosity, conductivity and refractive index were determined monthly for 3 months. The shelf-life of the nanoemulsion formulation was determined by accelerated stability testing. Results: The droplet size, conductivity, viscosity, pH and refractive index of the optimized formulations did not change significantly (p > 0.05) after 3 months of storage at room temperature (25 °C). The shelf life was 1.83 years at room temperature. Conclusion: The study demonstrates that the physical and chemical stability of BD is enhanced when it is formulated as a nanoemulsion.
- Subjects
CHEMICAL stability; EMULSION testing; MICROEMULSIONS; BECLOMETHASONE dipropionate; STABILIZING agents
- Publication
Tropical Journal of Pharmaceutical Research, 2015, Vol 14, Issue 1, p15
- ISSN
1596-5996
- Publication type
Article
- DOI
10.4314/tjpr.v14i1.3