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- Title
MicroRNA let-7 and viral infections: focus on mechanisms of action.
- Authors
Letafati, Arash; Najafi, Sajad; Mottahedi, Mehran; Karimzadeh, Mohammad; Shahini, Ali; Garousi, Setareh; Abbasi-Kolli, Mohammad; Sadri Nahand, Javid; Tamehri Zadeh, Seyed Saeed; Hamblin, Michael R.; Rahimian, Neda; Taghizadieh, Mohammad; Mirzaei, Hamed
- Abstract
MicroRNAs (miRNAs) are fundamental post-transcriptional modulators of several critical cellular processes, a number of which are involved in host defense mechanisms. In particular, miRNA let-7 functions as an essential regulator of the function and differentiation of both innate and adaptive immune cells. Let-7 is involved in several human diseases, including cancer and viral infections. Several viral infections have found ways to dysregulate the expression of miRNAs. Extracellular vesicles (EV) are membrane-bound lipid structures released from many types of human cells that can transport proteins, lipids, mRNAs, and miRNAs, including let-7. After their release, EVs are taken up by the recipient cells and their contents released into the cytoplasm. Let-7-loaded EVs have been suggested to affect cellular pathways and biological targets in the recipient cells, and can modulate viral replication, the host antiviral response, and the action of cancer-related viruses. In the present review, we summarize the available knowledge concerning the expression of let-7 family members, functions, target genes, and mechanistic involvement in viral pathogenesis and host defense. This may provide insight into the development of new therapeutic strategies to manage viral infections.
- Publication
Cellular & Molecular Biology Letters, 2022, Vol 27, Issue 1, p1
- ISSN
1425-8153
- Publication type
Article
- DOI
10.1186/s11658-022-00317-9