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- Title
Effects of CPAP on nitrate and norepinephrine levels in severe and mild-moderate sleep apnea.
- Authors
Pinto, Paula; Bárbara, Cristina; Montserrat, Joseph M.; Patarrão, Rita S.; Guarino, Maria P.; Carmo, Miguel M.; Macedo, Maria P.; Martinho, Cristina; Dias, Rita; Gomes, Maria J. M.
- Abstract
Background: Reduced plasma nitrate (NOx) levels and increased urinary norepinephrine (U-NE) levels have been described in severe obstructive sleep apnea (OSA), and are reverted by continuous positive airway pressure (CPAP). The effect of CPAP on these biomarkers in mild-moderate OSA is not well understood. The aim of this study was to compare NOx and U-NE levels and blood pressure (BP) between male patients with mild-moderate and severe OSA and determine the impact of 1 month of CPAP therapy on these parameters. Methods: We undertook a prospective study of 67 consecutive OSA patients (36 mild-moderate, 31 severe). Measurements of plasma NOx at 11 pm, 4 am and 7 am, 24-h U-NE and ambulatory BP were obtained at baseline and after 1 month of CPAP. Results: At baseline, NOx levels showed a significant decrease during the night in both groups (p < 0.001). U-NE level and BP were significantly higher in the severe OSA group. After 1 month of CPAP, there was a significant increase in NOx levels and a reduction in U-NE level and BP only in patients with severe OSA. Conclusions: One month of CPAP results in significant improvements in NOx levels, 24-h U-NE level and BP in patients with severe OSA, but not in patients with mild-moderate OSA. Trial registration: ClinicalTrials.gov: NCT01769807
- Subjects
SLEEP apnea syndromes; PHYSIOLOGICAL effects of nitrates; BLOOD plasma; BLOOD pressure; BIOMARKERS; NORADRENALINE; CLINICAL trials
- Publication
BMC Pulmonary Medicine, 2013, Vol 13, Issue 1, p1
- ISSN
1471-2466
- Publication type
Article
- DOI
10.1186/1471-2466-13-13