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- Title
Effect of epidural dexmedetomidine in single-dose combined with ropivacaine for cesarean section.
- Authors
Liu, Minghao; Chen, Xuezi; Guo, Dan
- Abstract
Background: Dexmedetomidine has arousal sedation and analgesic effects. We hypothesize that epidural dexmedetomidine in single-dose combined with ropivacaine improves the experience of parturient undergoing cesarean section under epidural anesthesia. This study is to investigate the effect of 0.5 µg/kg epidural dexmedetomidine combined with epidural anesthesia (EA) in parturients undergoing cesarean section. Methods: A total of 92 parturients were randomly divided into Group R (receiveing epidural ropivacaine alone) Group RD (receiveing epidural ropivacaine with 0.5 µg/kg dexmedetomidine). The primary outcome and second outcome will be intraoperative NRS pain scores and Ramsay Sedation Scale. Results: All 92 parturients were included in the analysis. The NRS were significantly lower in Group RD compared to Group R at all observation timepoint (P > 0.05). Higher Ramsay Sedation Scale was found in Group RD compared to Group R (P < 0.001). No parturient has experienced sedation score of 4 and above. No significant difference regarding the incidence of hypotension, bradycardia and nausea or vomiting, Apgar scores and the overall satisfaction with anesthesia was found between Group R and Group RD (P > 0.05). Conclusion: Epidural dexmedetomidine of 0.5 µg/kg added slightly extra analgesic effect to ropivacaine in EA for cesarean section. The sedation of 0.5 µg/kg epidural dexmedetomidine did not cause mother-baby bonding deficit. Satisfaction with anesthesia wasn't significantly improved by epidural dexmedetomidine of 0.5 µg/kg. No additional side effect allows larger dose of epidural dexmedetomidine attempt. Trial registration: This study was registered at www.chictr.org.cn (ChiCTR2000038853).
- Subjects
CESAREAN section; COMBINATION drug therapy; RESEARCH funding; ROPIVACAINE; STATISTICAL sampling; BLIND experiment; TREATMENT effectiveness; DESCRIPTIVE statistics; RANDOMIZED controlled trials; MOTHER-infant relationship; PARENT-infant relationships; PAIN management; WOMEN'S health; IMIDAZOLES; EPIDURAL anesthesia; ANESTHESIA; PREGNANCY
- Publication
BMC Anesthesiology, 2024, Vol 24, Issue 1, p1
- ISSN
1471-2253
- Publication type
Article
- DOI
10.1186/s12871-024-02519-4