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- Title
Quality of life assessment in patients with HNF1A-MODY and GCK-MODY.
- Authors
Szopa, Magdalena; Matejko, Bartlomiej; Ucieklak, Damian; Uchman, Agata; Hohendorff, Jerzy; Mrozińska, Sandra; Głodzik, Wojciech; Zapała, Barbara; Płatek, Teresa; Solecka, Iwona; Sani, Cyrus M; Małecki, Maciej T.
- Abstract
Aim: The impact of maturity onset diabetes of the young (MODY) on quality of life (QoL) has never been examined. We assessed disease impact on QoL among patients with HNF1A-MODY and GCK mutation carrier status. Methods: The study included 80 patients with HNF1A-MODY and 89 GCK gene mutation carriers. We also examined 128 type 1 diabetes (T1DM) patients for comparison. Diabetes-specific QoL was assessed using the Audit of Diabetes Dependent Quality of Life questionnaire. Results: HNF1A-MODY and GCK-MODY groups had similar mean age (41.7 vs. 38.0 years, respectively) and BMI (24.1 vs. 24.3 kg/m2), whereas T1DM patients were on average younger (34.2 years) with similar BMI (25.0 kg/m2). Less than a third of GCK mutation carriers were on pharmacotherapy (n = 20, 31%), while the majority of HNF1A mutation carriers used oral drugs or insulin (n = 66, 82.5%). While current QoL was similar across the three groups (p = 0.66), two other major indices—the impact of diabetes on QoL and the average weighted impact (AWI)—differed among them (p < 0.001 for both comparisons). The impact of diabetes on patient QoL and AWI observed in both MODY groups was smaller than in T1DM. Etiological diagnosis of diabetes and a diagnosis of retinopathy were the only independent factors influencing the impact of diabetes on QoL and AWI in regression analysis. In HNF1A-MODY, all three major indices of QoL were more heavily influenced for patients on insulin in comparison to other treatment sub-groups. Conclusion: MODY has a smaller negative impact on QoL compared to T1DM. Mode of treatment further stratifies QoL decline for HNF1A-MODY subjects.
- Publication
Endocrine (1355008X), 2019, Vol 64, Issue 2, p246
- ISSN
1355-008X
- Publication type
Article
- DOI
10.1007/s12020-018-1812-0