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- Title
DSB proteins and bacterial pathogenicity.
- Authors
Heras, Begoña; Shouldice, Stephen R.; Totsika, Makrina; Scanlon, Martin J.; Schembri, Mark A.; Martin, Jennifer L.
- Abstract
If DNA is the information of life, then proteins are the machines of life — but they must be assembled and correctly folded to function. A key step in the protein-folding pathway is the introduction of disulphide bonds between cysteine residues in a process called oxidative protein folding. Many bacteria use an oxidative protein-folding machinery to assemble proteins that are essential for cell integrity and to produce virulence factors. Although our current knowledge of this machinery stems largely from Escherichia coli K-12, this view must now be adjusted to encompass the wider range of disulphide catalytic systems present in bacteria.
- Subjects
PROTEIN folding; PROTEINS; MICROBIAL virulence; DNA; ESCHERICHIA coli; PATHOGENIC bacteria
- Publication
Nature Reviews Microbiology, 2009, Vol 7, Issue 3, p215
- ISSN
1740-1526
- Publication type
Article
- DOI
10.1038/nrmicro2087