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- Title
Hepatopancreatoduodenectomy for Locally Advanced Gallbladder Cancer: Is It Worthwhile?
- Authors
Zhou, Yanming; Li, Dianqi; You, Jun; Zeng, Siyuan; Yu, Wenlin
- Abstract
The benefit of hepatopancreatoduodenectomy for locally advanced gallbladder cancer was unclear. An electronic search was conducted in PubMed, Ovid, and the Cochrane Library for the relevant publications reported in the literature between January 1990 and November 2021. Twenty-two studies involving 126 patients met the inclusion criteria. Major and minor hepatectomies were performed in 45.6% and 54.4% patients respectively. R0 (microscopically negative margin) resection was achieved in 74.6% patients. The morbidity and 90-day mortality rates were 60.1% and 8.7% respectively. The median overall survival after surgery was 18 months. Multivariate analysis showed that R0 resection was the only independent prognostic factor for survival (hazard ratio 0.115, 95% confidence intervals 0.030–0.445; P = 0.002). Hepatopancreatoduodenectomy was suggested in patients with locally advanced gallbladder cancer provided that R0 resection can be achieved.
- Subjects
ONLINE information services; MEDICAL databases; GALLBLADDER tumors; CONFIDENCE intervals; SYSTEMATIC reviews; MULTIVARIATE analysis; DISEASES; TREATMENT effectiveness; DESCRIPTIVE statistics; MEDLINE; PANCREATICODUODENECTOMY; HEPATECTOMY
- Publication
Indian Journal of Surgery, 2022, Vol 84, p535
- ISSN
0972-2068
- Publication type
Article
- DOI
10.1007/s12262-022-03471-8