We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Imprinted M6p/Igf2 receptor is mutated in rat liver tumors.
- Authors
Mills, J J; Falls, J G; De Souza, A T; Jirtle, R L
- Abstract
We have previously shown that inactivation of mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) is a common early event in both human liver and breast carcinogenesis. The M6p/Igf2r is imprinted in mice while expression is biallelic in most humans. In this investigation the M6p/Igf2r gene is shown to also be imprinted in the liver of Fischer 344, Lewis and Brown Norway rats. In addition, we have identified mutations in the expressed allele of the M6p/Igf2r in 40% of diethylnitrosamine-initiated rat liver tumors. These results provide further evidence that the M6P/IGF2R functions as a liver tumor suppressor gene. They also suggest that mice and rats would be more sensitive than humans to those hepatocarcinogens in which the M6p/Igf2r is mechanistically involved in transformation since one rather than two alleles would need to be inactivated.
- Subjects
CANCER genetics; CARCINOGENESIS; LIVER cancer; BREAST cancer
- Publication
Oncogene, 1998, Vol 16, Issue 21, p2797
- ISSN
0950-9232
- Publication type
Article
- DOI
10.1038/sj.onc.1201801