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- Title
Comparison of Plasma Concentrations of Posaconazole with the Oral Suspension and Tablet in Korean Patients with Hematologic Malignancies.
- Authors
Hyeon Jeong Suh; Inho Kim; Joo-Youn Cho; Sang-ln Park; Seo Hyun Yoon; Jeong-Ok Lee; Youngil Koh; Kyoung-Ho Song; Pyoeng Gyun Choe; Kyung-Sang Yu; Eu Suk Kim; Hong Bin Kim; Soo-Mee Bang; Nam Joong Kim; Sang Hoon Song; Wan Beom Park; Myoung-don Oh
- Abstract
The posaconazole tablet formulation was developed to have improved bioavailability compared to the oral suspension. Here, we compared posaconazole plasma concentration (PPC) with the posaconazole oral suspension versus the tablet in Korean patients undergoing remission induction chemotherapy for hematologic malignancies. PPC was measured at 3, 8, and 15 days of treatment with the oral suspension (174 patients) or the tablet (40 patients). At all time-points, mean PPC was significantly higher with the tablet compared to the oral suspension. Our findings suggest that posaconazole tablets generate an optimal PPC earlier and in more patients than the oral suspension among Korean patients.
- Subjects
HEMATOLOGIC malignancies; TRIAZOLES; ORAL medication; DRUG bioavailability; CANCER chemotherapy; THERAPEUTICS
- Publication
Infection & Chemotherapy, 2017, Vol 49, Issue 2, p135
- ISSN
2093-2340
- Publication type
Article
- DOI
10.3947/ic.2017.49.2.135