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- Title
Multivariate determination of CO/CO ratios in exhaled mouse breath with mid-infrared hollow waveguide gas sensors.
- Authors
Seichter, Felicia; Wilk, Andreas; Wörle, Katharina; Kim, Seong-Soo; Vogt, Josef; Wachter, Ulrich; Radermacher, Peter; Mizaikoff, Boris
- Abstract
The CO/CO isotope ratio is a well-known marker in breath for a variety of biochemical processes and enables monitoring, e.g., of the glucose metabolism during sepsis. Using animal models-here, at a mouse intensive care unit-the simultaneous determination of CO and CO within small volumes of mouse breath was enabled by coupling a novel low-volume hollow waveguide gas cell to a compact Fourier transform infrared spectrometer combined with multivariate data evaluation based on partial least squares regression along with optimized data preprocessing routines.
- Subjects
CARBON monoxide detectors; CARBON isotopes; FOURIER transform infrared spectroscopy; LEAST squares; WAVEGUIDES; MULTIVARIATE analysis
- Publication
Analytical & Bioanalytical Chemistry, 2013, Vol 405, Issue 14, p4945
- ISSN
1618-2642
- Publication type
Article
- DOI
10.1007/s00216-013-6824-2