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- Title
Synthesis of Four Diastereomers of Sclerophytin F and Structural Reassignment of Several Sclerophytin Natural Products.
- Authors
Clark, J. Stephen; Delion, Laëtitia; Farrugia, Louis J.
- Abstract
Synthesis of the triol that has been proposed to be the marine natural product sclerophytin F has been completed along with the syntheses of three diastereomers. Comparison of the NMR spectroscopic data for all four compounds to the data reported for the natural product reveals that sclerophytin F is not the 3 S diastereomer of sclerophytin A as proposed by Friedrich and Paquette. Re-analysis of the NMR spectroscopic data for known sclerophytin natural products and synthetic analogues leads to the conclusion that sclerophytins E and F are the same compound. This finding has allowed structural reassignment of several other cladiellin natural products.
- Subjects
DIASTEREOISOMERS synthesis; NUCLEAR magnetic resonance spectroscopy; MARINE natural products; DATA analysis; CHEMICALS
- Publication
Chemistry - A European Journal, 2015, Vol 21, Issue 12, p4772
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201406051