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- Title
Copper-Catalyzed Arylation of Nitrogen Heterocycles from Anilines under Ligand-Free Conditions.
- Authors
Toummini, Dounia; Tlili, Anis; Bergès, Julien; Ouazzani, Fouad; Taillefer, Marc
- Abstract
The arylation of pyrazole and derivatives can be achieved by coupling arenediazonium species (formed in situ from anilines) by using a catalytic system that employs low-toxicity and inexpensive copper metal under very mild and ligand-free conditions ( T=20 °C). From other nitrogen heterocycles, the presence of an additive (NBu4I) significantly improves the efficiency of the catalytic system. These results represent the first examples of CN bond formation from arenediazonium species.
- Subjects
HETEROCYCLIC compounds synthesis; ARYLATION; NITROGEN compound synthesis; COPPER catalysts; PYRAZOLES; ANILINE; CATALYSIS
- Publication
Chemistry - A European Journal, 2014, Vol 20, Issue 45, p14619
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201404982