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- Title
An Easy‐to‐Fabricate Hydrogel Platform with Tunable Stiffness and Cell Anchorage: Validation of Its Feasibility in Modulating Sonic Hedgehog Signaling Pathway Physically.
- Authors
Yu, Tingting; Hu, Ke; Xu, Qiufan; Xu, Xueqin; Du, Chunyue; Zhao, Yinyi; Yan, Sen; Wang, Wei; Tang, Shijia; Yue, Shen; Zhang, Xiya; Wang, Danlei; Zhang, Feimin; Cheng, Steven Yan; Gu, Ning
- Abstract
An Easy-to-Fabricate Hydrogel Platform with Tunable Stiffness and Cell Anchorage: Validation of Its Feasibility in Modulating Sonic Hedgehog Signaling Pathway Physically B Back Cover b : In article number 1900759, Feimin Zhang, Steven Yan Cheng, Ning Gu, and co-workers develop an IPN hydrogel group with gradient stiffness and cell anchor points, and report that the matrix stiffness and adhesion property functions as key regulators to determine the final output of "Sonic Hedgehog" (Shh) signaling. These results indicate the feasibility of applying this hydrogel platform to low-cost, high throughput screening of signal pathways which are responsive to the biophysical changes of microenvironments.
- Subjects
ANCHORAGE; STIFFNESS (Engineering); FEASIBILITY studies; RAILROAD signals; CELLS
- Publication
Macromolecular Materials & Engineering, 2020, Vol 305, Issue 4, p1
- ISSN
1438-7492
- Publication type
Article
- DOI
10.1002/mame.201900759