We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Surgical margin status of specimen and oncological outcomes after laparoscopic radical prostatectomy: experience after 400 procedures.
- Authors
Porpiglia, Francesco; Fiori, Cristian; Manfredi, Matteo; Grande, Susanna; Poggio, Massimiliano; Bollito, Enrico; Papotti, Mauro; Scarpa, Roberto
- Abstract
Purpose: To analyse the surgical margins status of prostatic glands, resected by laparoscopic radical prostatectomy (LRP) for prostate cancer, and to correlate it with biochemical free survival rate (BFSR). Methods: Data were collected prospectively from 405 patients undergoing LRP from 2000 to 2009 at a single institution. Patients undergoing neoadjuvant and/or adjuvant therapy were excluded from the study. Three hundred patients matched all the criteria: 232 of these had negative surgical margins (NSM) and 68 positive surgical margins (PSM). The median follow-up was 62 months. PSM were classified based on the following: (a) the number of margins, monofocal and multifocal, (b) the location, apical or non-apical and (c) the extension, ≤2.8 mm or >2.8 mm. These data were then entered into a multivariate analysis. Results: Overall BFSR rate was 67.6% in PSM group and 88.8% in NSM group ( P < 0.001). We registered a HR of 3.78 in multivariate analysis ( P < 0.001). In terms of the extension, BFSR in univariate survival analysis was 77.8% in ≤2.8 mm PSM and 38.9% in >2.8 mm PSM ( P = 0.003), with a HR of 5.68 ( P = 0.011) in multivariate analysis. BFSR was 59% for apical margins and 77% for non-apical margins ( P = 0.038). In monofocal margins, BFSR was 73%, while 53% in multifocal ( P = 0.014). Conclusions: We recommend careful evaluation of patients with PSM following LRP, especially if they are more than 2.8 mm, and in these cases, adjuvant therapy should be considered after radical surgery.
- Subjects
PROSTATE surgery; PROSTATE cancer; HEALTH outcome assessment; PROSTATECTOMY; LAPAROSCOPIC surgery; ADJUVANT treatment of cancer; MULTIVARIATE analysis
- Publication
World Journal of Urology, 2012, Vol 30, Issue 2, p245
- ISSN
0724-4983
- Publication type
Article
- DOI
10.1007/s00345-011-0711-2