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- Title
Comparison of quiet breathing and controlled ventilation in the high-resolution CT assessment of airway disease in infants with cystic fibrosis.
- Authors
Long, Frederick R.; Williams, Roger S.; Adler, Brent H.; Castile, Robert G.
- Abstract
<bold>Background: </bold>Respiratory motion and low lung volumes limit the quality of HRCT examinations in infants and young children.<bold>Objective: </bold>To assess the effects of respiratory motion and lung inflation on the ability to diagnose airway abnormalities and air trapping (AT) using HRCT in infants with cystic fibrosis (CF).<bold>Materials and Methods: </bold>HRCT images of the lungs were obtained at four anatomical levels in 16 sedated children (age 2.4+/-1.1 years, mean+/-SD) with CF using controlled ventilation at full lung inflation (CVCT-I), at resting end exhalation (CVCT-E), and during quiet breathing (CT-B). Two blinded reviewers independently and then by consensus scored all images for the presence or absence of bronchiectasis (BE), bronchial wall thickening (BWT), and AT.<bold>Results: </bold>Of the 64 images evaluated, BE was identified in 19 (30%) of the CVCT-I images compared to 6 (9%) of the CVCT-E images (P=0.006) and 4 (6%) of the CT-B images (P=0.044). AT was seen in 29 (45%) of the CVCT-E images compared to 14 (22%) of the CVCT-I images (P=0.012) and 12 (19%) of the CT-B images (P=0.012). There were no significant differences in the detection of BWT among the three methods.<bold>Summary: </bold>In infants with CF, fully inflating the lung improved the ability to diagnose early BE, and obtaining motion-free images at end exhalation enhanced the detection of AT.
- Subjects
AIRWAY (Anatomy); INFANT diseases; CYSTIC fibrosis; TOMOGRAPHY; VENTILATION; RESPIRATION; DISEASES; COMPARATIVE studies; COMPUTED tomography; RESEARCH methodology; MEDICAL cooperation; RESEARCH; RESEARCH evaluation; RESPIRATORY obstructions; EVALUATION research; BODY movement; BLIND experiment; RESPIRATORY mechanics; MEDICAL artifacts; DISEASE complications
- Publication
Pediatric Radiology, 2005, Vol 35, Issue 11, p1075
- ISSN
0301-0449
- Publication type
journal article
- DOI
10.1007/s00247-005-1541-4