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- Title
Optical Resolution of Rimantadine.
- Authors
Han, Jianlin; Takeda, Ryosuke; Sato, Tatsunori; Moriwaki, Hiroki; Abe, Hidenori; Izawa, Kunisuke; Soloshonok, Vadim A.
- Abstract
This work discloses a new procedure for the resolution of commercially available racemic rimantadine hydrochloride to enantiomerically pure (S)-rimantadine using (R)-phenoxypropionic acid as a recyclable resolving reagent. Good chemical yields, operational ease, and low-cost structure underscore the preparative value of this method for the production of enantiomerically pure rimantadine for medicinal or synthetic studies.
- Subjects
RIMANTADINE; AMINO acids; X-ray diffraction; NANOPARTICLES; ENANTIOSELECTIVE catalysis
- Publication
Molecules, 2019, Vol 24, Issue 9, p1828
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules24091828