We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Inhibition of Inflammatory Mediators by Neobavaisoflavone in Activated RAW264.7 Macrophages.
- Authors
Szliszka, Ewelina; Skaba, Dariusz; Czuba, Zenon P.; Krol, Wojciech
- Abstract
Flavonoids and coumarins are the major bioactive constituents identified in Psoralea corylifolia. The active fraction isolated from fruits, seeds and roots possesses antibacterial, antioxidative and immunomodulatory properties. Neobavaisoflavone is one of the flavonoids found in Psoralea corylifolia. In the present study we investigated in vitro the anti-inflammatory activity of neobavaisoflavone. Macrophages play an important role in inflammation through the release of inflammatory mediators involved in the immune response. Inappropriate and prolonged macrophage activation is largely responsible for the pathology of acute and chronic inflammatory conditions. Neobavaisoflavone significantly inhibited the production of reactive oxygen species (ROS), reactive nitrogen species (RNS) and cytokines: IL-1β, IL-6, IL-12p40, IL-12p70, TNF-α in LPS+IFN-γ- or PMA- stimulated RAW264.7 macrophages.
- Subjects
FLAVONOIDS; COUMARINS; PSORALEA; LEGUMES; OXYGEN
- Publication
Molecules, 2011, Vol 16, Issue 5, p3701
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules16053701