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- Title
Reduction of Alzheimer's Disease Amyloid-β in Plasma by Hemodialysis and Its Relation to Cognitive Functions.
- Authors
Kitaguchi, N.; Kawaguchi, K.; Nakai, S.; Murakami, K.; Ito, S.; Hoshino, H.; Hori, H.; Ohashi, A.; Shimano, Y.; Suzuki, N.; Yuzawa, Y.; Mutoh, T.; Sugiyama, S.
- Abstract
Background/Aims: Rapid removal of plasma amyloid-β (Aβ) by blood purification may serve as a peripheral Aβ sink from the brain for Alzheimer's disease therapy. We investigated the reduction of plasma Aβ during hemodialysis and cognitive states. Methods: Aβ concentrations and Mini-Mental State Examinations (MMSE) were investigated in 37 hemodialysis patients (68.9 ± 4.1 years). Results: The dialyzers effectively removed Aβ1-40 and Aβ1-42, 63.9 ± 14.4 and 51.6 ± 17.0% at 4 h dialysis, resulting in the reduction of Aβs in whole-body circulation by 51.1 ± 8.9 and 32.7 ± 12.0%, respectively. Although the plasma Aβs before dialysis (750.8 ± 171.3 pg/ml for Aβ1-40) were higher than those reported for Alzheimer's disease patients, the cognitive states of hemodialysis patients were relatively normal, especially of longer dialysis vintages. Conclusions: Dialyzers effectively reduced Aβs in whole-body circulation. Repeated rapid decrease of plasma Aβs might maintain cognitive state. Copyright © 2011 S. Karger AG, Basel
- Subjects
ALZHEIMER'S disease; AMYLOID; AMYLOID beta-protein; HEMAPHERESIS; DIALYSIS (Chemistry)
- Publication
Blood Purification, 2011, Vol 32, Issue 1, p57
- ISSN
0253-5068
- Publication type
Article
- DOI
10.1159/000322624