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- Title
Synthesis and Antitumor Activity of a Novel Series of Helicid-Pyrrolidone Derivatives.
- Authors
Jiang, Li-Juan; Lv, Shi-Ming; Cheng, Chao; Dong, Lin; Li, Ying; Yin, Shu-Fan
- Abstract
This paper reports the synthesis of a new series of helicid-pyrrolidone derivatives ( 4a-4d, 5a-5d, and 6a-6d), which were tested for antitumor activity against human skov3 cell. In this study, two compounds ( 4b and 6c) demonstrate high antitumor activity against this cell line having IC values of 0.22 and 6.5 μM, respectively, which are lower than those of an inhibitor of heat shock protein 90 (17AAG), currently under clinical evaluation for cancer treatment.
- Subjects
PYRROLIDINONES; PYRROLIDINE; ANTINEOPLASTIC agents; CANCER treatment; HEAT shock proteins; BIOSYNTHESIS
- Publication
Chemistry of Natural Compounds, 2015, Vol 51, Issue 1, p121
- ISSN
0009-3130
- Publication type
Article
- DOI
10.1007/s10600-015-1216-9