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- Title
Effect of Helicobacter pylori Eradication on Body Weight: A Multicenter Propensity Score-matched Analysis in Korea.
- Authors
Jong Wook Kim; Myong Ki Baeg; Chang Seok Bang; Jong-Kyu Park; Jung-Hwan Oh
- Abstract
Background/Aims There is growing interest in whether Helicobacter pylori eradication (HPE) can affect body weight. Methods Data from 5 universities between January 2013 and December 2019 were analyzed retrospectively. H. pylori -positive subjects who had body weight measurements taken at least twice at intervals of 3 months or longer were included. Using propensity score (PS)-matched data, changes in body mass index (BMI) and the lipid profile after HPE were compared with the non-HPE group. Results Among 363 eligible patients, 131 HPE patients were PS-matched to 131 non-HPE patients. The median intervals between the measurements were 610 (range, 154-1250) days and 606 (range, 154-1648) days in the HPE and non-HPE groups, respectively. In both groups, the mean BMI increased (from 24.5 kg/m² to 24.7 kg/m² in the HPE group, and from 24.4 kg/m² to 24.5 kg/m² in the non-HPE group). The 2 groups did not show significantly different changes (P = 0.921). In the lowest baseline BMI quartile, the BMI increased after HPE by 1.23 (standard deviation [SD], 3.72) kg/m² (P = 0.060), and the non-HPE group showed a decreased BMI at the time of follow-up (by -0.24 [SD, 5.25] kg/m²; P = 0.937) (between-group P = 0.214). Triglyceride levels increased after HPE (mean: 135 [SD, 78] to 153 [SD, 100] mg/dL; between-group P = 0.053). Conclusion The overall BMI change was not significantly different between the HPE and non-HPE groups, but patients with low BMI showed a tendency to gain weight after HPE. Triglyceride levels increased after HPE with marginal significance.
- Subjects
SOUTH Korea; HELICOBACTER pylori; BODY weight; BODY mass index; WEIGHT gain; INTERVAL measurement
- Publication
Journal of Neurogastroenterology & Motility, 2023, Vol 29, Issue 3, p352
- ISSN
2093-0879
- Publication type
Article
- DOI
10.5056/jnm22179