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- Title
A green organocatalyzed one-pot protocol for efficient synthesis of new substituted pyrimido[4,5- d]pyrimidinones using a Biginelli-like reaction.
- Authors
Rimaz, Mehdi; Khalafy, Jabbar; Mousavi, Hossein
- Abstract
In this article, we have demonstrated a green and facile one-pot approach for the regio- and chemoselective synthesis of 5-aryloyl-1,3-dimethyl-7-thioxo-5,6,7,8-tetrahydropyrimido[4,5- d]pyrimidine-2,4(1 H,3 H)-dione derivatives in water at 50 °C. This transformation presumably proceeds via a three-component tandem annulation of arylglyoxalmonohydrates with 1,3-dimethylbarbituric acid and thiourea in the presence of catalytic amounts of DABCO or l-proline, involving a Biginelli-like reaction. Graphical Abstract:
- Subjects
ORGANOCATALYSIS; CHEMOSELECTIVITY; PYRIMIDINE derivatives; CATALYTIC activity; CHEMICAL reactions; SUBSTITUENTS (Chemistry)
- Publication
Research on Chemical Intermediates, 2016, Vol 42, Issue 12, p8185
- ISSN
0922-6168
- Publication type
Article
- DOI
10.1007/s11164-016-2588-6