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- Title
Can the immune system be harnessed to repair the CNS?
- Authors
Popovich, Phillip G.; Longbrake, Erin E.
- Abstract
Experimental and clinical data have demonstrated that activating the immune system in the CNS can be destructive. However, other studies have shown that enhancing an immune response can be therapeutic, and several clinical trials have been initiated with the aim of boosting immune responses in the CNS of individuals with spinal cord injury, multiple sclerosis and Alzheimer's disease. Here, we evaluate the controversies in the field and discuss the remaining scientific challenges that are associated with enhancing immune function in the CNS to treat neurological diseases.
- Subjects
IMMUNE system; CENTRAL nervous system; IMMUNE response; CLINICAL trials; SPINAL cord injuries; DISEASES in older people
- Publication
Nature Reviews Neuroscience, 2008, Vol 9, Issue 6, p481
- ISSN
1471-003X
- Publication type
Article
- DOI
10.1038/nrn2398