We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
外泌体与皮肤创伤的修复.
- Authors
肖梓腾; 王婷禹; 张雯雯; 谭凤怡; 苏海威; 李思婷; 吴雅慧; 周艳芳; 彭新生
- Abstract
BACKGROUND: Exosomes play a role in all stages of wound repair, and there is currently a large body of research on exosomes in skin wound repair, which has been shown to have great potential for clinical applications. OBJECTIVE: To summarize and discuss the main mechanisms and clinical applications of exosomes in the treatment of skin wounds, in order to promote the clinical translation of exosomes. METHODS: PubMed, clinicaltrials.gov, China National Knowledge Infrastructure, Food and Drug Administration database, and Chinese Clinical Trial Register were searched from inception to March 2023. The English search terms were “exosomes, wound healing, stem cells, chronic wound, immunoregulation, inflammation, skin, therapeutic use, isolation, characterization, infections”. The Chinese search terms were “exosomes, wound healing, stem cells, immunomodulation, clinical applications”. A total of 79 articles were included for the summary. RESULTS AND CONCLUSION: (1) Exosomes can improve and accelerate wound healing through inflammation regulation, immune protection, angiogenesis, cell proliferation and migration, and collagen remodeling. (2) Exosomes derived from stem cells have mature preparation techniques and related mechanism research, which is currently the mainstream research direction. Non-stem cell-derived exosomes have the advantages of convenience, economy, and easy production, and can be used as a supplement for clinical applications. (3) The clinical application of exosomes is still in its infancy, but has great potential for application. Various exosome modification techniques have laid the foundation for the future development of clinically personalized services and require further research. (4) The clinical translation of exosomes faces many challenges, such as low yield, high heterogeneity, lack of unified standards for isolation, purification, and quality control, and difficulties in storage.
- Subjects
CHINA; WOUND healing; UNITED States. Food &; Drug Administration; CELL migration; DATABASE administration; EXOSOMES; CLINICAL medicine; STEM cells; SKIN regeneration
- Publication
Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu, 2024, Vol 28, Issue 19, p3104
- ISSN
2095-4344
- Publication type
Article
- DOI
10.12307/2024.144