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- Title
Lab‐in‐a‐Bead: Magnetic Janus Bead Probe for the Detection of Biomarkers in Blood.
- Authors
Gunatilake, Udara Bimendra; Caballe‐Abalos, Adriana; Garcia‐Rey, Sandra; Mercader‐Ruiz, Jon; Basabe‐Desmonts, Lourdes; Benito‐Lopez, Fernando
- Abstract
Remotely handled miniaturized colorimetric sensor platforms with multiple functionalities are able to mimic conventional laboratory operations with reduced assets. The integration of a magnetic phase in a miniaturized hydrogel sensor system allows the manipulation of the sensor, under a magnetic field, in a programmable manner. However, dark color interferences from conventional magnetic phases (Fe3O4, Fe2O3, and Fe micro/nanoparticles) affect the signal readout, hindering the colorimetric response. Therefore, a novel Janus bead configuration is introduced and tested by the localized incorporation of ferromagnetic iron microparticles into a TiO2 nanotubes/alginate hydrogel bead biosystem, under an applied magnetic field. The so‐called hydrogel Janus bead shows both, magnetic translocation and biosensing properties in the same bead. These beads are used for the direct colorimetric analysis of biomarkers in blood. The surface of the Janus bead prevents the biofouling of red blood cells, keeping the sensor surface clean for accurate optical colorimetric analysis. Moreover, the external magnetic manipulation of the bead permits precise control of the time and position of the bead in the sample. Therefore, multiple functionalities are presented by a single magnetic TiO2 nanotubes/alginate Janus bead such as actuation, low biofouling, and sensing, positioning this technology as a truly Lab‐in‐a‐Bead System.
- Subjects
COLORIMETRIC analysis; ERYTHROCYTES; TRANSCRANIAL magnetic stimulation; SURFACE cleaning; BIOMARKERS; IRON
- Publication
Advanced Materials Interfaces, 2023, Vol 10, Issue 34, p1
- ISSN
2196-7350
- Publication type
Article
- DOI
10.1002/admi.202202459