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- Title
Endogenous ligands for C-type lectin receptors: the true regulators of immune homeostasis.
- Authors
García-Vallejo, Juan J.; Kooyk, Yvette van
- Abstract
C-type lectin receptors (CLRs) have long been known as pattern-recognition receptors implicated in the recognition of pathogens by the innate immune system. However, evidence is accumulating that many CLRs are also able to recognize endogenous ‘self’ ligands and that this recognition event often plays an important role in immune homeostasis. In the present review, we focus on the human and mouse CLRs for which endogenous ligands have been described. Special attention is given to the signaling events initiated upon recognition of the self ligand and the regulation of glycosylation as a switch modulating CLR recognition, and therefore, immune homeostasis.
- Subjects
LECTINS; PATTERN perception; PATHOGENIC microorganisms; IMMUNE system; LIGANDS (Biochemistry); HOMEOSTASIS; DENDRITIC cells
- Publication
Immunological Reviews, 2009, Vol 230, Issue 1, p22
- ISSN
0105-2896
- Publication type
Article
- DOI
10.1111/j.1600-065X.2009.00786.x