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- Title
Effect of gene conversion on polymorphic patterns at major histocompatibility complex loci.
- Authors
Ohta, Tomoko
- Abstract
The pattern of polymorphisms at MHC loci was studied by computer simulation and by DNA sequence analyses, with special reference to synonymous and non-synonymous divergence among alleles. A model of overdominance plus short-term selection was simulated for a gene family with allelic and non-allelic gene conversion. It was found that the ratio of non-synonymous-to-synonymous divergence among alleles decreases as the non-allelic conversion becomes more frequent. On the other hand, the ratio of synonymous divergence at the antigen recognition site to that at non-coding region increases by non-allelic conversion. By comparing such a pattern with the observed values of mammalian genes, it is suggested that non-allelic conversion is less frequent in human genes than in genes of other mammals. A quantitative analysis on the patchwork pattern was attempted by usign identity excess among nucleotide sites of a gene. Comparison of simulation results with DNA data analysis shows that the rate of allelic conversion is high.
- Subjects
GENETIC polymorphisms; MAJOR histocompatibility complex
- Publication
Immunological Reviews, 1999, Vol 167, Issue 1, p319
- ISSN
0105-2896
- Publication type
Article
- DOI
10.1111/j.1600-065X.1999.tb01401.x