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- Title
Signet-ring cell carcinoma of the appendix with ganglioneuromatosis: a case report.
- Authors
Sato, Ayami; Sato, Yu; Hiruta, Nobuyuki; Oshiro, Takashi; Yoshida, Yutaka; Urita, Tasuku; Kitahara, Tomoaki; Kadoya, Kengo; Nabekura, Taiki; Moriyama, Yuki; Okazumi, Shinichi
- Abstract
Background: Primary cancer of the appendix, especially signet-ring cell carcinoma, is an uncommon disease, and it is rarely suspected before surgery. Diffuse intestinal ganglioneuromatosis that is not associated with neurofibromatosis-1 or multiple endocrine neoplasia 2b is also rare. The most frequent symptoms caused by it are changes in bowel habits, abdominal pain, and occlusive episodes. Case presentation: The patient was a 48-year-old woman who had a month-long history of chronic abdominal pain, fullness, constipation, and diarrhoea. Enhanced computed tomography showed a 100-mm irregular swelling in the appendix and thickening of the appendiceal wall with cystic dilatation. Based on a preoperative diagnosis of appendiceal cancer, the patient underwent laparoscopic ileocecal resection with D3 lymph node dissection. Pathological diagnosis revealed a signet-ring cell carcinoma of the appendix with ganglioneuromatosis. The patient completed four courses of capecitabine plus oxaliplatin (CAPEOX) as postoperative adjuvant chemotherapy, and 23-month postoperative outcome was noneventful without recurrence. Conclusion: We report a signet-ring cell carcinoma of the appendix that was detected early because of its presence with ganglioneuromatosis.
- Subjects
IRRITABLE colon; LYMPHADENECTOMY; CARCINOMA; ADJUVANT chemotherapy; LAPAROSCOPIC surgery; RARE diseases
- Publication
Surgical Case Reports, 2022, Vol 8, Issue 1, p1
- ISSN
2198-7793
- Publication type
Case Study
- DOI
10.1186/s40792-022-01509-3