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- Title
Macrophage Activation in Follicular Conjunctivitis during the COVID-19 Pandemic.
- Authors
Gallenga, Carla Enrica; Maritati, Martina; Mura, Marco; Di Virgilio, Francesco; Conti, Pio; Contini, Carlo
- Abstract
Among the symptoms of SARS-CoV-2, follicular conjunctivitis has become relevant. The conjunctiva acts as an open lymph node, reacting to the viral antigen that binds the epithelial cells, forming follicles of B cells with activated T cells and NK cells on its surface, which, in turn, talk to monocyte-derived inflammatory infected macrophages. Here, the NLRP3 inflammasome is a major driver in releasing pro-inflammatory factors such as IL-6 and caspase-1, leading to follicular conjunctivitis and bulbar congestion, even as isolated signs in the 'asymptomatic' patient.
- Subjects
COVID-19 pandemic; MACROPHAGE activation; KILLER cells; EPITHELIAL cells; CONJUNCTIVITIS; T cells; B cells; T cell receptors; AVIAN influenza
- Publication
Microorganisms, 2023, Vol 11, Issue 9, p2198
- ISSN
2076-2607
- Publication type
Article
- DOI
10.3390/microorganisms11092198