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- Title
ANTI-BIOFILM STRATEGY: MEROPENEM MODULATES BIOFILM FORMATION IN Acinetobacter lwoffii.
- Authors
Musafer, Hadeel
- Abstract
Objectives: Numerous studies investigated multi-drug resistance and biofilm formation, but not determined the concentration of antibiotics which can be as anti-biofilm. Acinetobacter lwoffii is opportunistic pathogen that is caused increasing rate of hospital-acquired infections. Methods: A. lwoffii isolates from urinary tract infection are MDR. Results: A. lwoffii was resistance to all antibiotics that were tested. The planktonic cells of A. lwoffii 1 and A. lwoffii 7 show resistance (256 and 32) μg/ ml toward meropenem and levofloxacin respectively, as well as strong resistance (ND) for ceftazidime, amikacin and gentamicin. The biofilm cells MICs results were significantly P < 0.005 higher than the planktonic MICs. Pattern of biofilm ability for #1 and #7 with 2 μg/ ml meropenem and without showed great tendency to shape a biofilm, where A. lwoffii 1 (1.1) followed by A. lwoffii 7 (1.07). Conclusion: An interesting observation was the formation of biofilm showed enormous decline at a concentration 32 μg /ml with the presence of meropenem. The intracellular secondary messenger c-di-GMP also significantly declined with meropenem 32 μg /ml, hence, this confirm the estimation that meropenem affect biofilm formation.
- Subjects
MULTIDRUG resistance in bacteria; BIOFILMS; ANTIBIOTICS; ACINETOBACTER lwoffii; URINARY tract infections; MEROPENEM
- Publication
Pakistan Journal of Biotechnology, 2018, Vol 15, Issue 4, p879
- ISSN
1812-1837
- Publication type
Article