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- Title
The orthorhombic pseudopolymorph of tacrine hydrochloride.
- Authors
Jacobs, Jeroen; Moris, Michele; De Samber, Tim; Vrijdag, Johannes; De Borggraeve, Wim; Van Meervelt, Luc
- Abstract
Crystallization of tacrine hydrochloride, an acetylcholinesterase inhibitor used during treatment of mild to moderate Alzheimer's disease, from a water:ethanol solution has resulted in an orthorhombic pseudopolymorph. This orthorhombic form which occurs as a dihydrate shows columns of stacking acridines together with continuous Cl—Owater—Owater—Cl chains and ladder-like ribbons composed of squares and hexagons.
- Subjects
TACRINE hydrochloride; CRYSTALLIZATION; ACETYLCHOLINESTERASE inhibitors
- Publication
Acta Crystallographica Section B: Structural Science, Crystal Engineering & Materials, 2016, Vol 72, Issue 5, p771
- ISSN
2052-5192
- Publication type
Article
- DOI
10.1107/S2052520616011094