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- Title
Detection of human cytomegalovirus ( CMV) DNA in feces has limited value in predicting CMV enteritis in patients with intestinal graft-versus-host disease after allogeneic stem cell transplantation.
- Authors
Sun, Y.‐Q.; Xu, L.‐P.; Han, T.‐T.; Zhang, X.‐H.; Wang, Y.; Han, W.; Wang, F.‐R.; Wang, J.‐Z.; Chen, H.; Chen, Y.‐H.; Yan, C.‐H.; Chen, Y.; Liu, K.‐Y.; Huang, X.‐J.
- Abstract
Background Cytomegalovirus ( CMV) enteritis after allogeneic hematopoietic stem cell transplantation (allo- HSCT) is difficult to diagnose. We aimed to evaluate the sensitivity and specificity of the detection of CMV DNA in feces for predicting CMV enteritis. Methods HSCT patients with intestinal graft-versus-host disease ( GVHD) were enrolled if they met the following criteria: (i) underwent a colonoscopy and (ii) peripheral blood and feces specimens were available for CMV DNA detection within 24 h of colonoscopy. The colonoscopy histology was used as the gold standard for diagnosing CMV enteritis. Results Fifty-six patients underwent 58 colonoscopy examinations, and 7 were diagnosed as having CMV enteritis. Within 24 h of colonoscopy, 9 patients had detectable CMV in the feces and 19 patients had detectable CMV in the plasma, respectively. In the 7 patients with CMV enteritis, only 2 had detectable CMV in the stool, resulting in a sensitivity of 28.6%. In the 51 patients without CMV enteritis, 44 had no detectable CMV in the stool, with a specificity of 86.3%. Conclusion We concluded that CMV detection in the feces was not a good predictor of CMV enteritis in patients with intestinal GVHD after allo- HSCT.
- Subjects
STEM cell transplantation research; DIARRHEA; CYTOMEGALOVIRUSES; GRAFT versus host disease; FECES
- Publication
Transplant Infectious Disease, 2015, Vol 17, Issue 5, p655
- ISSN
1398-2273
- Publication type
Article
- DOI
10.1111/tid.12420