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- Title
Multicenter study for brain/body hypothermia for hypoxic-ischemic encephalopathy: Changes in HMGB-1.
- Authors
Nakamura, Toshihiko; Asanuma, Hideomi; Kusuda, Satoshi; Imai, Ken; Hosono, Shigeharu; Kato, Ryota; Suzuki, Satoshi; Yokoi, Kyoko; Kokubo, Minoru; Yamada, Shingo; Kamohara, Takashi
- Abstract
Background We measured changes in the blood level of high-mobility group box-1 ( HMGB-1) at 24 h intervals in neonates treated with brain/body hypothermia (body hypothermia therapy: BHT) for hypoxic-ischemic encephalopathy ( HIE), to evaluate the usefulness of HMGB-1 level for determining outcomes. Methods We studied 15 neonates with HIE who underwent BHT ( BHT (+) group) and six neonates with HIE who did not ( BHT (-) group). We recorded HMGB-1 changes at 24 h intervals, creatinine phosphokinase, and the resistance index of the anterior cerebral artery. Magnetic resonance imaging ( MRI) was used to determine short-term outcome. Result Baseline HMGB-1 was significantly higher in the BHT (+) group than in the BHT (-) group. Thereafter, HMGB-1 in the BHT (+) group significantly decreased at 24 h intervals, reaching the reference range by 2 days of age. In the BHT (+) group, when patients were classified into clinically significant neurological disorder due to HIE (+) and (-) according to MRI, the neurological disorder (+) group had higher mean HMGB-1. Conclusions In HIE, HMGB-1 differs according to the presence of BHT, suggesting that HMGB-1 measurement soon after birth might be useful for determining BHT necessity and short-term outcome.
- Subjects
BRAIN injury treatment; TREATMENT effectiveness; CREATINE kinase; INDUCED hypothermia; MAGNETIC resonance imaging; MEDICAL cooperation; RECOMBINANT proteins; RESEARCH; CATHELICIDINS; ANTERIOR cerebral artery; BLOOD
- Publication
Pediatrics International, 2017, Vol 59, Issue 10, p1074
- ISSN
1328-8067
- Publication type
Article
- DOI
10.1111/ped.13377