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- Title
CD30+ large cell transformation of mycosis fungoides after psoralen plus ultraviolet A photochemotherapy.
- Authors
Ogino, J.; Saga, Kenji; Kagaya, M.; Kamada, A.; Hirosaki, K.; Kaneko, R.; Jimbow, K.
- Abstract
Psoralen plus ultraviolet A (PUVA) photochemotherapy is widely used for the therapy of mycosis fungoides (MF). Clinical progression of MF is often associated with an increase in the size of tumour cells known as transformation. We report two patients with CD30+ large cell transformation that appeared after low-dose PUVA therapy for MF. Clinical data, histopathology, immunohistopathology and T-cell receptor gene rearrangement were studied. Nodules consisted of atypical large cells that expressed CD30. Monoclonal rearrangement of T-cell receptors was observed in one case. Low-dose PUVA therapy may be associated with CD30+ large cell transformation in patients with MF.
- Subjects
CELL transformation; MYCOSIS fungoides; PSORALENS; ULTRAVIOLET photography; PHOTOCHEMOTHERAPY; T-cell receptor genes
- Publication
British Journal of Dermatology, 2007, Vol 156, Issue 1, p148
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/j.1365-2133.2006.07566.x