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- Title
ETHANOL INDUCES HIGHER BEC IN CB<sub>1</sub> CANNABINOID RECEPTOR KNOCKOUT MICE WHILE DECREASING ETHANOL PREFERENCE.
- Authors
Lallemand, F.; De Witte, P.
- Abstract
Aims: Previous studies have shown that CB1 cannabinoid receptors are involved in the behavioural effects induced by chronic ethanol administration in Wistar rats by using SR 141716, a CB1 cannabinoid receptor antagonist. These studies have now been extended to investigate the effect of acute and chronic alcoholization on blood ethanol concentration (BEC) and ethanol preference in CB1 knockout (-/--) mice. Methods: BEC was monitored for a period of 8 h in both CB1-/- male mice and CB1 male wild-type (+/+) mice, which had received an acute i.p. injection of ethanol in 1, 3 or 5 g/kg doses. Ethanol preference was assayed in both groups of male mice in non-forced ethanol administration and forced chronic pulmonary alcohol administration for 14 and 39 days, respectively. Results: After an acute intraperitoneal ethanol injection of 5 g/kg, CB1-/- mice showed a significant higher BEC during the ethanol elimination stage than the CB1+/+ mice. However, those in the 1 and 3 g/kg groups showed no significant difference. A 2-3 fold increase in BEC was observed in CB1-/- mice on days 10 and 11 after commencement of forced chronic pulmonary alcoholization in comparison with CB1+/+ mice, although comparable BEC values were assayed in both groups on day 12. In addition, these CB1-/- mice showed a significantly lower preference for ethanol than CB1+/+ mice. Conclusions: The studies on CB1-/- and CB1+/+ mice have clearly confirmed the involvement of CB1 receptor on ethanol induced behavioural effects and also revealed that CB1 receptors may be implicated in ethanol absorption/distribution, particularly after administration of high ethanol doses.
- Subjects
CANNABINOIDS; CANNABIS (Genus); ALCOHOL; MICE; ALCOHOL drinking; ALCOHOLISM
- Publication
Alcohol & Alcoholism, 2005, Vol 40, Issue 1, p54
- ISSN
0735-0414
- Publication type
Article
- DOI
10.1093/alcalc/agh115