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- Title
ADVANCED GLYCATION END-PRODUCTS IN PATIENTS WITH CHRONIC ALCOHOL MISUSE.
- Authors
Marta, Kalousová; Tomáš, Zima; Petr, Popov; Pavel, Špaček; Martin, Braun; Jiřina, Soukupová; Květa, Pelinkova; Rosemarie, Kientsch-Engel
- Abstract
Aims: The aim of our study was to determine serum levels of advanced glycation end-products (AGE) in patients with chronic alcohol misuse and to examine their relationship to markers of nutrition and inflammation. Methods: The study group consisted of 23 heavy alcohol drinkers treated for chronic alcohol misuse and 22 healthy controls. Studied parameters included AGE (fluorescence, CML - carboxymethyllysine and pentosidine), lipids, glucose, albumin, leptin, prealbumin, C-reactive protein (CRP) and pregnancy-associated plasma protein A (PAPP-A). Results: AGE fluorescence was significantly higher in chronic alcoholic patients than in healthy subjects (4.3 ± 0.7 × 10³ vs 3.7 ± 0.5 × 10³ AU/g protein. P < 0.005), while CML was only slightly but not significantly elevated (569.1 ± 106.6 vs 545.5 ± 85.8 μg/l) and pentosidine levels did not differ (105.4 ± 29 vs 102.2 ± 23 nmol/l). In alcoholics, AGE correlate significantly negatively with leptin (r = -0.46, P < 0.05) and pentosidine with prealbumin (r = -0.43, P <0.05), otherwise there was no relationship between AGE and other biochemical parameters (glucose, cholesterol, albumin, CRP, PAPP-A). Conclusion: Our findings suggest a more complex relationship among advanced glycation, oxidative stress and metabolism of ethanol and their link to nutrition and nutrition-associated parameters. AGE as a result of oxidative stress might be similarly linked to increased cardiovascular risk of heavy alcohol drinkers, as are malnutrition and inflammation; however, further studies are needed to confirm this hypothesis.
- Subjects
ALCOHOL drinking; C-reactive protein; PEOPLE with alcoholism; SERUM; DIGESTION; LEPTIN
- Publication
Alcohol & Alcoholism, 2004, Vol 39, Issue 4, p316
- ISSN
0735-0414
- Publication type
Article
- DOI
10.1093/alcalc/agh058