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- Title
A prospective, randomized trial comparing the Vienna nomogram to an eight-core prostate biopsy protocol.
- Authors
Lecuona, Angus; Heyns, Chris F.
- Abstract
OBJECTIVE • To compare prostate cancer detection rates using the Vienna nomogram versus an8-core prostate biopsy protocol. To compare the complication rates of transrectal prostate biopsy in the two groups. PATIENTS AND METHODS • In a prospective randomized trial, men with a serum PSA ≥ 2.5 ng/ml were stratified according to serum PSA (I = PSA 2.5–10; II = PSA 10.1–30; III =PSA 30.1–50 ng/mL) and were then randomized to group A (number of cores determined according tothe Vienna nomogram) or group B (8-core prostate biopsy). • Statistical analysis was performed using Student’s t-test for parametric data, Mann- Whitney test for nonparametric data and Fisher’s exact test for contingency tables. A two-tailed p-value <0.05 was accepted as statistically significant. RESULTS• In the period July 2006 to July 2009, 303 patients were randomized to group A (n = 152) or group B (n= 151). There wereno significant differences in serum PSA, prostate volume, PSA density or post-biopsycomplications between the groups. • The cancer detection rate was lower ingroup A than in group B for the whole study cohort (35.5% vs 38.4%), for those with PSA < 10 ng/ml (28.1% vs 33%) and for those with prostate volume > 50 ml (22% vs 25.8%). These differences were notstatistically significant (NSS). CONCLUSION • These findings suggest that there is nosignificant advantage in using the Vienna nomogram to determine the number of prostate biopsy cores to be taken, compared to an 8-core biopsy protocol.
- Subjects
PROSTATE cancer; U-statistics; NOMOGRAPHY (Mathematics); CANCER complications; HEMATURIA; THERAPEUTICS
- Publication
BJU International, 2011, Vol 108, Issue 2, p204
- ISSN
1464-4096
- Publication type
Article
- DOI
10.1111/j.1464-410X.2010.09887.x