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- Title
Adalimumab-Induced Cutaneous Lupus Erythematosus in a 16-Year-Old Girl with Juvenile Idiopathic Arthritis.
- Authors
West, Emily S.; Nanda, Kabita; Ofodile, Ope; Rutledge, Joe; Brandling‐Bennett, Heather A.
- Abstract
Tumor necrosis factor α ( TNF-α) antagonists are used in the treatment of numerous autoimmune conditions. Adalimumab is the first monoclonal antibody to TNF-α and is used to treat juvenile idiopathic arthritis. A growing body of literature associates anti- TNF-α therapies with several adverse dermatologic manifestations, including drug-induced lupus erythematosus (LE). We describe a case of cutaneous LE in a 16-year-old girl treated with adalimumab for juvenile idiopathic arthritis. The temporal association between her presenting symptoms and adalimumab initiation and gradual improvement after stopping biologic therapy suggest adalimumab-induced cutaneous LE. With increasing use of anti- TNF therapies in children, the potential for drug-induced LE should not be overlooked.
- Subjects
ADALIMUMAB; TUMOR necrosis factors; ARTHRITIS diagnosis; DRUG-induced abnormalities; ALTERNATIVE treatment for immunologic diseases; PREVENTION
- Publication
Pediatric Dermatology, 2015, Vol 32, Issue 4, pe140
- ISSN
0736-8046
- Publication type
Article
- DOI
10.1111/pde.12576