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- Title
Oestrogen receptor α genotype, and interactions between vitamin D receptor and transforming growth factor-β1 genotypes are associated with quantitative calcaneal ultrasound in postmenopausal women.
- Authors
Koh, Jung-min; Nam-Goong, Seong; Hong, Jeong Soo; Kim, Hong-kyu; Jae Seung Kim, Hong-kyu; Shin-Yoon Kim; Ghi Su Kim
- Abstract
Quantitative ultrasound (QUS) of bone is a new radiation-free, low-cost method that measures both bone mass and quality. We investigated associations between QUS parameters and polymorphisms of vitamin D receptor (VDR), oestrogen receptor α (ERα) and transforming growth factor-β1 (TGF-β1) genes in postmenopausal women residing in a community. QUS and anthropometric characteristics were measured in postmenopausal women, and compared with regard to the VDR, ERα and TGF-β1 genotypes. Among the 552 women who participated in the population-based Chung-Up osteoporosis prevalence study, 206 postmenopausal women, aged 60–69 years, were included. Broadband ultrasound attenuation (BUA) and speed of sound (SOS) were measured at the left calcaneus using QUS measurement of bone, and a stiffness index (SI) was calculated. We determined the BsmI and FokI polymorphisms of VDR gene and the XbaI and PvuII polymorphisms of ERα gene using the polymerase chain reaction-restriction fragment length polymorphism method, and Τ29 → C polymorphism of TGF-β1 gene using an allele-specific polymerase chain reaction assay. The XbaI polymorphism of ERα gene was significantly associated with SI (T-score) and BUA ( P = 0·040 and P = 0·024, respectively). There were no significant differences in any QUS parameters among the genotypes of VDR and TGF-β1. However, significant genetic interactions between the VDR and TGF-β1 genotypes, were noted ( P = 0·017 for SI and P = 0·028 for BUA between the BsmI and Τ29 → C polymorphisms; P = 0·038 for SI and P = 0·035 for BUA between the FokI and T29 → C polymorphisms). The combined genotypes between the BsmI and T29 → C polymorphisms or between the FokI and T29 → C polymorphisms, were significantly associated with the QUS parameters. This study indicates that the XbaI polymorphism of ERα gene may influence the Quantitative ultrasound parameters in postmenopausal women, and suggests the need for further investigations about the interactions between the VDR and TGF-β1 genes.
- Subjects
ESTROGEN; GENOTYPE-environment interaction; VITAMIN D; OSTEOPOROSIS in women; INTRAVASCULAR ultrasonography; GENETICS
- Publication
Clinical Endocrinology, 2004, Vol 60, Issue 2, p232
- ISSN
0300-0664
- Publication type
Article
- DOI
10.1046/j.1365-2265.2003.01972.x