We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Induction of cell stress through gene transfer of an engineered heat shock transcription factor enhances tumor immunogenicity.
- Authors
Gough, M. J.; Melcher, A. A.; Crittenden, M. R.; Sanchez-Perez, L.; Voellmy, R.; Vile, R. G.
- Abstract
Heat shock protein expression and release is closely associated with immunogenic forms of cell death. We show that activation of the stress response within tumor cells during cell death, using an engineered form of the heat shock transcription factor, leads to an immunogenic death. Cells dying through ‘stressful death’ show decreased phagocytosis by macrophages in vitro. Moreover, cells expressing heat shock proteins during cell death are significantly more protective against subsequent tumor challenge. These data demonstrate the utility of activating cellular stress programs over the course of cytotoxic therapies to enhance immune responses to dying cells.Gene Therapy (2004) 11, 1099-1104. doi:10.1038/sj.gt.3302274 Published online 22 April 2004
- Subjects
CELL death; CANCER cells; HEAT shock proteins; ENZYME induction; TRANSCRIPTION factors; IMMUNE response; RETICULO-endothelial system; PHAGOCYTOSIS; CELLULAR immunity
- Publication
Gene Therapy, 2004, Vol 11, Issue 13, p1099
- ISSN
0969-7128
- Publication type
Article
- DOI
10.1038/sj.gt.3302274