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- Title
Viewpoint: Lupus anticoagulant detection and interpretation in antiphospholipid syndrome.
- Authors
Efthymiou, Maria; Bertolaccini, Maria Laura; Cohen, Hannah
- Abstract
Lupus anticoagulant (LA) is a well-established risk factor for the clinical manifestations of antiphospholipid syndrome (APS). Accurate LA detection is an essential prerequisite for optimal diagnosis and management of patients with APS or aPL carriers. Variability remains a challenge in LA testing, with reliable detection influenced by multiple factors, including pre-analytical conditions, anticoagulation treatment, choice of tests and procedures performed, as well as interpretation of results, that can lead to false-positives or negatives. A standardised approach to LA testing, following current guidance, based on published data and international consensus, and with attention to detail, is required to underpin accurate detection of LA. Future work should focus on better characterisation of the nature of LA, which may ultimately lead to improved diagnosis and management of patients with APS and aPL carriers. This article reviews current practice and challenges, providing an overview on detection of LA.
- Subjects
ANTIPHOSPHOLIPID syndrome treatment; AUTOANTIBODIES; CLINICAL pathology; THROMBOSIS; PROTHROMBIN time; BLOOD coagulation tests; ANTIPHOSPHOLIPID syndrome; ANTICOAGULANTS; MEDICAL protocols; SYSTEMIC lupus erythematosus; DIAGNOSTIC errors; DISEASE risk factors; SYMPTOMS
- Publication
Rheumatology, 2024, Vol 63, pSI54
- ISSN
1462-0324
- Publication type
Article
- DOI
10.1093/rheumatology/kead623