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- Title
Tipping the metabolic scales towards increased longevity in mammals.
- Authors
Riera, Celine E.; Dillin, Andrew
- Abstract
A hallmark of ageing is dysfunction in nutrient signalling pathways that regulate glucose homeostasis, negatively affecting whole-body energy metabolism and ultimately increasing the organism's susceptibility to disease. Maintenance of insulin sensitivity depends on functional mitochondrial networks, but is compromised by alterations in mitochondrial energy metabolism during ageing. Here we discuss metabolic paradigms that influence mammalian longevity, and highlight recent advances in identifying fundamental signalling pathways that influence metabolic health and ageing through mitochondrial perturbations.
- Subjects
ANIMAL models for aging; HOMEOSTASIS; METABOLISM; MITOCHONDRIAL pathology; AGE of mammals
- Publication
Nature Cell Biology, 2015, Vol 17, Issue 3, p196
- ISSN
1465-7392
- Publication type
Article
- DOI
10.1038/ncb3107