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- Title
In vivo reprogramming of astrocytes to neuroblasts in the adult brain.
- Authors
Niu, Wenze; Zang, Tong; Zou, Yuhua; Fang, Sanhua; Smith, Derek K.; Bachoo, Robert; Zhang, Chun-Li
- Abstract
Adult differentiated cells can be reprogrammed into pluripotent stem cells or lineage-restricted proliferating precursors in culture; however, this has not been demonstrated in vivo. Here, we show that the single transcription factor SOX2 is sufficient to reprogram resident astrocytes into proliferative neuroblasts in the adult mouse brain. These induced adult neuroblasts (iANBs) persist for months and can be generated even in aged brains. When supplied with BDNF and noggin or when the mice are treated with a histone deacetylase inhibitor, iANBs develop into electrophysiologically mature neurons, which functionally integrate into the local neural network. Our results demonstrate that adult astrocytes exhibit remarkable plasticity in vivo, a feature that might have important implications in regeneration of the central nervous system using endogenous patient-specific glial cells.
- Subjects
ASTROCYTES; PLURIPOTENT stem cells; NEUROGLIA; GREEN fluorescent protein; GLIAL fibrillary acidic protein
- Publication
Nature Cell Biology, 2013, Vol 15, Issue 10, p1164
- ISSN
1465-7392
- Publication type
Article
- DOI
10.1038/ncb2843