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- Title
Auxin triggers a genetic switch.
- Authors
Lau, Steffen; Smet, Ive De; Kolb, Martina; Meinhardt, Hans; Jürgens, Gerd
- Abstract
Cell specification in development requires robust gene-regulatory responses to transient signals. In plants, the small signalling molecule auxin has been implicated in diverse developmental processes. Auxin promotes the degradation of AUXIN/INDOLE-3-ACETIC ACID (AUX/IAA) inhibitors that prevent AUXIN RESPONSE FACTOR (ARF) transcription factors from regulating their target genes. However, the precise role of auxin in patterning has remained unclear, the view of auxin acting as a morphogen is controversial and the transcriptional control of the ARF genes themselves is barely explored. Here, we demonstrate by experimental and computational analyses that the Arabidopsis ARF protein MONOPTEROS (MP) controls its own expression and the expression of its AUX/IAA inhibitor BODENLOS (BDL), with auxin acting as a threshold-specific trigger by promoting the degradation of the inhibitor. Our results suggest a general mechanism for how the transient accumulation of auxin activates self-sustaining or hysteretic feedback systems of interacting auxin-response proteins that, similarly to other genetic switches, result in unequivocal developmental responses.
- Subjects
AUXIN; INDOLE; MOLECULAR cell differentiation; ACETIC acid; MORPHOGENESIS; TRANSCRIPTION factors; GENETIC transcription regulation
- Publication
Nature Cell Biology, 2011, Vol 13, Issue 5, p611
- ISSN
1465-7392
- Publication type
Article
- DOI
10.1038/ncb2212