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- Title
The cellular and molecular basis of store-operated calcium entry.
- Authors
Venkatachalam, Kartik; van Rossum, Damian B.; Patterson, Randen L.; Ma, Hong-Tao; Gill, Donald L.
- Abstract
The impact of calcium signalling on so many areas of cell biology reflects the crucial role of calcium signals in the control of diverse cellular functions. Despite the precision with which spatial and temporal details of calcium signals have been resolved, a fundamental aspect of the generation of calcium signals — the activation of 'store-operated channels' (SOCs) — remains a molecular and mechanistic mystery. Here we review new insights into the exchange of signals between the endoplasmic reticulum (ER) and plasma membrane that result in activation of calcium entry channels mediating crucial long-term calcium signals.
- Subjects
CALCIUM; CYTOLOGY; CELL membranes; ENDOPLASMIC reticulum
- Publication
Nature Cell Biology, 2002, Vol 4, Issue 11, pE263
- ISSN
1465-7392
- Publication type
Article
- DOI
10.1038/ncb1102-e263