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- Title
A pro-inflammatory role of Fcα/μR on marginal zone B cells in sepsis.
- Authors
Akira Shibuya; Shin-ichiro Honda; Kazuko Shibuya
- Abstract
Fc receptors play important roles for a wide array of immune responses. In contrast to the well-defined Fcγ and Fce receptors, the molecular and functional characteristics of Fc receptors for IgA and IgM have remained incompletely understood for years. Recent progress has unveiled the characteristics of Fc receptors for IgA and IgM, including Fcα/μ receptor (Fcα/μR) (CD351), polymeric immunoglobulin receptor (poly-IgR), Fcα receptor (FcαRI) (CD89) and Fcμ receptor (FcμR). In this review, we summarize the molecular and functional characteristics of Fcα/μR in comparison with poly-IgR, FcμR and FcαRI, and focus particularly on the pro-inflammatory function of Fcα/μR expressed on marginal zone B cells in sepsis.
- Subjects
CELL receptors; SEPTICEMIA treatment; IMMUNOGLOBULIN A; IMMUNOGLOBULIN M; THERAPEUTIC use of immunoglobulins; THERAPEUTICS
- Publication
International Immunology, 2017, Vol 29, Issue 11, p519
- ISSN
0953-8178
- Publication type
Article
- DOI
10.1093/intimm/dxx059