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- Title
A new light on DNA replication from the inactive X chromosome.
- Authors
Aladjem, Mirit I.; Fu, Haiqing
- Abstract
While large portions of the mammalian genome are known to replicate sequentially in a distinct, tissue-specific order, recent studies suggest that the inactive X chromosome is duplicated rapidly via random, synchronous DNA synthesis at numerous adjacent regions. The rapid duplication of the inactive X chromosome was observed in high-resolution studies visualizing DNA replication patterns in the nucleus, and by allele-specific DNA sequencing studies measuring the extent of DNA synthesis. These studies conclude that inactive X chromosomes complete replication earlier than previously thought and suggest that the strict order of DNA replication detected in the majority of genomic regions is not preserved in non-transcribed, 'silent' chromatin. These observations alter current concepts about the regulation of DNA replication in non-transcribed portions of the genome in general and in the inactive X-chromosome in particular.
- Subjects
DNA replication; X chromosome; GENOMES; DNA synthesis; CELL nuclei; NUCLEOTIDE sequencing; EPIGENETICS
- Publication
BioEssays, 2014, Vol 36, Issue 6, p591
- ISSN
0265-9247
- Publication type
Article
- DOI
10.1002/bies.201400021